Genetic architecture and resulting phenotype

The Navarini Lab uses a two-pronged approach of analysing genetic and visual data to understand skin conditions.

This page aims to inform and update you about our activities. If you have similar interests, we are always looking for collaborations. Also, the page is a home for the reference assistant that we consider a significant advance for scientific writing - why don't you try it yourself?

Utilizing exome-wide next generation sequencing allows us to detect disease driving genetic alterations. These are then taken forward for functional analysis, which sometimes can lead to novel therapeutic approaches. Our main focus of conditions are the neutrophil-mediated inflammatory diseases (NMID) including pustular psoriasis, pyoderma gangrenosum, Sweet syndrome and others. Other projects include additional immune-mediated conditions.

Our Vision-Team also seeks to extract objective insights out of imaging, which are the dermatologists' most valuable data. We use systematic evaluation of common skin conditions with new visual tools such as dermoscopy as well as machine-learning techniques that enabled us to develop eczema-detecting algorithms.

With these two central themes, we aim towards optimised genotype-phenotype correlations and clinical insights that could be useful for future decision support systems.

Recent posts

“The main interest of this laboratory is inflammatory skin disease. My clinical and research activity is focused around these diseases that make up a large fraction of the cases treated at our department.”

Alexander Navarini, Prof. Dr. med. Dr. sc.nat.

“We have initiated a new consultation for genodermatoses building on our expertise in modern genomics and are accepting referrals.”

Alexander Navarini , Prof. Dr. med. Dr. sc.nat.