Generalized pustular psoriasis (A), acrodermatitis continua Hallopeau (B), palmoplantar pustulosis (C) and undefined pustulosis (D)
The Navarini Lab's research
is focused on understanding and addressing inflammatory,
especially pustular, skin conditions.
The focus of our activities is the investigation of inflammatory skin disease, especially neutrophil-mediated inflammatory dermatoses (NMID). We have two groups of investigators working on projects addressing genetic & pathophysiological questions (NMID-Team), as well as a newer and smaller Vision-Team whose aim is to transform visual information into quantifiable phenotypic data.
Our two PhD students Rebecca Higgins and Adhideb Ghosh use whole exome sequencing and bioinformatic search approaches to detect causative genetic alterations in a whole range of inflammatory skin conditions. Currently in the pipeline are linear localized scleroderma, acneiform skin conditions, pyoderma gangrenosum, Sweet syndrome, pustular psoriasis and primary immunodeficiencies. See each person’s detailed information and the project page for further information.
On the clinical side of the NMID projects, clinician-scientist Florian Anzengruber, Mathias Drach, Julia-Tatjana Maul and several doctoral (MD) and master students contribute as well.
Since several years, we are also interested in the visual-phenotypical aspects of skin conditions. We use machine-learning approaches to detect skin lesions, 3D techniques to reconstruct spatial images and other types of spectral imaging to detect new aspects of skin diseases. Moritz Klinger, Amrei Klemmer and recently also Florian Anzengruber drive these approaches forward. We enjoy fruitful close collaborations with the ETHZ (Marc Pollefeys and Martin Oswald) as well as the HSLU (Marc Pouly, Thomas Koller and colleagues).
Many skin diseases and questions related to them cannot be addressed effectively working alone. In fact, most of our research is done in collaborations. We are glad to be part of the Swiss Dermatology Network of Targeted Therapy (SDNTT), European Rare and Severe Psoriasis Expert Network (ERASPEN, PI Navarini), and have helped to start the international registry for toxic epidermal necrolysis (IRTEN). Also, we help to drive forward the production of Swiss clinical guidelines including for psoriasis and rosacea.
Apart from large consortia, we have productive personal collaborations with a range of fantastic colleagues – in recent years often by performing gene searches by whole exome sequencing for a larger project involving functional assays and sometimes even direct clinical translation.
From left to right, back row: Adhideb Ghosh, Kerstin Gutersohn, Florian Anzengruber, Tamsyn Meyer, Alexander Navarini, Barbara Fruet, Moritz Klinger. Front row: Rebecca Higgins, Jasmin Narainsing, Mathias Drach, Petra Greco, Eva Nagy-Andrassy